Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p235 | Genetics and Epigenetics | ECTS2016

Periostin serum levels and gene polymorphism are associated with bone microarchitecture

Pepe Jessica , Bonnet Nicolas , Herrmann Francois , Biver Emmanuel , Rizzoli Rene , Chevelley Thierry , Livio Ferrari Serge

Background: We previously reported that serum periostin levels are determined by additive genetic effects. Whether serum levels and/or SNPs in the periostin gene (Postn) contribute to bone microstructure however remains unknown.Aim: To investigate the association between periostin levels, Postn SNPs, bone-mass and bone microarchitecture in a cohort of postmenopausal women.Methods: A total of 648 postmenopausal women from the Geneva...